Indianapolis Colts vs San Francisco 49ers: Prediction, Head-to-Head, Odds & Stats (Tue, 23 Dec '25)
Wojtek Kolan
Published on 23 Dec, 01:15 AM UTC
Next Match 23/12/25 at 01:15 AM
Indianapolis Colts vs San Francisco 49ers
📍 Lucas Oil Stadium, USA.
Scheduled H2H Match For Indianapolis Colts Vs San Francisco 49ers
NFL
Tue, 23 Dec 2025 at 01:15 AM UTC
Indianapolis Colts
USA
Recent Form
W
W
W
W
L
3
Win
Played
4
0 Draws1
Win
4
Position
1
Shane Steichen
Manager
Kyle Shanahan
San Francisco 49ers
USA
Recent Form
W
W
W
W
W
3
Win
Played
4
0 Draws1
Win
4
Position
1
Shane Steichen
Manager
Kyle Shanahan
Game Schedule - Time Of Fixture
Indianapolis Colts will square off vs San Francisco 49ers in NFL on Tue, 23 Dec 2025 at 01:15 AM UTC. Let’s investigate historical performances, recent stats and head-2-head information to find out the most accurate picks and best bets.
Indianapolis Colts vs San Francisco 49ers H2H Match Summary
For the most recent 4 head-2-head matches for these teams, Indianapolis Colts have got the victory 3 times and San Francisco 49ers have won on 1 occasion. In the last game between them, Indianapolis Colts won 18-30.
| Head-to-Head | Match Wins |
|---|---|
| Indianapolis Colts | 3 |
| San Francisco 49ers | 1 |
Indianapolis Colts vs San Francisco 49ers Past H2H Matches
NFL
12:20 AM
25/10/21
25/10/21
San Francisco 49ers
18
Indianapolis Colts
30
05:00 PM
08/10/17
08/10/17
Indianapolis Colts
26
San Francisco 49ers
23
06:00 PM
25/11/01
25/11/01
Indianapolis Colts
21
San Francisco 49ers
40
NFL Preseason
08:30 PM
25/08/18
25/08/18
Indianapolis Colts
23
San Francisco 49ers
17
Indianapolis Colts Recent Matches
NFL (24 Matches)
05:00 PM
21/09/25
21/09/25
Tennessee Titans
20
Indianapolis Colts
41
W
08:05 PM
14/09/25
14/09/25
Indianapolis Colts
29
Denver Broncos
28
W
05:00 PM
07/09/25
07/09/25
Indianapolis Colts
33
Miami Dolphins
8
W
06:00 PM
05/01/25
05/01/25
Indianapolis Colts
26
Jacksonville Jaguars
23
W
06:00 PM
29/12/24
29/12/24
New York Giants
45
Indianapolis Colts
33
L
06:00 PM
22/12/24
22/12/24
Indianapolis Colts
38
Tennessee Titans
30
W
09:25 PM
15/12/24
15/12/24
Denver Broncos
31
Indianapolis Colts
13
L
06:00 PM
01/12/24
01/12/24
New England Patriots
24
Indianapolis Colts
25
W
06:00 PM
24/11/24
24/11/24
Indianapolis Colts
6
Detroit Lions
24
L
06:00 PM
17/11/24
17/11/24
New York Jets
27
Indianapolis Colts
28
W
06:00 PM
10/11/24
10/11/24
Indianapolis Colts
20
Buffalo Bills
30
L
01:20 AM
04/11/24
04/11/24
Minnesota Vikings
21
Indianapolis Colts
13
L
05:00 PM
27/10/24
27/10/24
Houston Texans
23
Indianapolis Colts
20
L
05:00 PM
20/10/24
20/10/24
Indianapolis Colts
16
Miami Dolphins
10
W
05:00 PM
13/10/24
13/10/24
Tennessee Titans
17
Indianapolis Colts
20
W
05:00 PM
06/10/24
06/10/24
Jacksonville Jaguars
37
Indianapolis Colts
34
L
05:00 PM
29/09/24
29/09/24
Indianapolis Colts
27
Pittsburgh Steelers
24
W
05:00 PM
22/09/24
22/09/24
Indianapolis Colts
21
Chicago Bears
16
W
05:00 PM
15/09/24
15/09/24
Green Bay Packers
16
Indianapolis Colts
10
L
05:00 PM
08/09/24
08/09/24
Indianapolis Colts
27
Houston Texans
29
L
01:15 AM
07/01/24
07/01/24
Indianapolis Colts
19
Houston Texans
23
L
06:00 PM
31/12/23
31/12/23
Indianapolis Colts
23
Las Vegas Raiders
20
W
06:00 PM
24/12/23
24/12/23
Atlanta Falcons
29
Indianapolis Colts
10
L
09:30 PM
16/12/23
16/12/23
Indianapolis Colts
30
Pittsburgh Steelers
13
W
NFL Preseason (6 Matches)
05:00 PM
23/08/25
23/08/25
Cincinnati Bengals
14
Indianapolis Colts
41
W
05:00 PM
16/08/25
16/08/25
Indianapolis Colts
19
Green Bay Packers
23
L
11:00 PM
07/08/25
07/08/25
Baltimore Ravens
24
Indianapolis Colts
16
L
12:00 AM
23/08/24
23/08/24
Cincinnati Bengals
14
Indianapolis Colts
27
W
11:00 PM
17/08/24
17/08/24
Indianapolis Colts
21
Arizona Cardinals
13
W
05:00 PM
11/08/24
11/08/24
Indianapolis Colts
30
Denver Broncos
34
L
San Francisco 49ers Recent Matches
NFL (24 Matches)
08:25 PM
21/09/25
21/09/25
San Francisco 49ers
16
Arizona Cardinals
15
W
05:00 PM
14/09/25
14/09/25
New Orleans Saints
21
San Francisco 49ers
26
W
08:05 PM
07/09/25
07/09/25
Seattle Seahawks
13
San Francisco 49ers
17
W
09:25 PM
05/01/25
05/01/25
Arizona Cardinals
47
San Francisco 49ers
24
L
01:15 AM
31/12/24
31/12/24
San Francisco 49ers
34
Detroit Lions
40
L
09:25 PM
22/12/24
22/12/24
Miami Dolphins
29
San Francisco 49ers
17
L
01:15 AM
13/12/24
13/12/24
San Francisco 49ers
6
Los Angeles Rams
12
L
09:25 PM
08/12/24
08/12/24
San Francisco 49ers
38
Chicago Bears
13
W
01:20 AM
02/12/24
02/12/24
Buffalo Bills
35
San Francisco 49ers
10
L
09:25 PM
24/11/24
24/11/24
Green Bay Packers
38
San Francisco 49ers
10
L
09:05 PM
17/11/24
17/11/24
San Francisco 49ers
17
Seattle Seahawks
20
L
06:00 PM
10/11/24
10/11/24
Tampa Bay Buccaneers
20
San Francisco 49ers
23
W
12:20 AM
28/10/24
28/10/24
San Francisco 49ers
30
Dallas Cowboys
24
W
08:25 PM
20/10/24
20/10/24
San Francisco 49ers
18
Kansas City Chiefs
28
L
12:15 AM
11/10/24
11/10/24
Seattle Seahawks
24
San Francisco 49ers
36
W
08:05 PM
06/10/24
06/10/24
San Francisco 49ers
23
Arizona Cardinals
24
L
08:05 PM
29/09/24
29/09/24
San Francisco 49ers
30
New England Patriots
13
W
08:25 PM
22/09/24
22/09/24
Los Angeles Rams
27
San Francisco 49ers
24
L
05:00 PM
15/09/24
15/09/24
Minnesota Vikings
23
San Francisco 49ers
17
L
12:15 AM
10/09/24
10/09/24
San Francisco 49ers
32
New York Jets
19
W
11:30 PM
11/02/24
11/02/24
Kansas City Chiefs
25
San Francisco 49ers
22
L
11:30 PM
28/01/24
28/01/24
San Francisco 49ers
34
Detroit Lions
31
W
01:15 AM
21/01/24
21/01/24
San Francisco 49ers
24
Green Bay Packers
21
W
09:25 PM
07/01/24
07/01/24
San Francisco 49ers
20
Los Angeles Rams
21
L
NFL Preseason (6 Matches)
12:30 AM
24/08/25
24/08/25
San Francisco 49ers
30
Los Angeles Chargers
23
W
08:00 PM
16/08/25
16/08/25
Las Vegas Raiders
19
San Francisco 49ers
22
W
12:30 AM
10/08/25
10/08/25
San Francisco 49ers
9
Denver Broncos
30
L
02:00 AM
24/08/24
24/08/24
Las Vegas Raiders
24
San Francisco 49ers
24
D
12:00 AM
19/08/24
19/08/24
San Francisco 49ers
16
New Orleans Saints
10
W
11:00 PM
10/08/24
10/08/24
Tennessee Titans
17
San Francisco 49ers
13
L
Indianapolis Colts Next Fixtures
NFL
08:05 PM
28/09/25
28/09/25
Los Angeles Rams
Indianapolis Colts
Prediction
05:00 PM
05/10/25
05/10/25
Indianapolis Colts
Las Vegas Raiders
Prediction
05:00 PM
12/10/25
12/10/25
Indianapolis Colts
Arizona Cardinals
Prediction
08:05 PM
19/10/25
19/10/25
Los Angeles Chargers
Indianapolis Colts
Prediction
08:25 PM
26/10/25
26/10/25
Indianapolis Colts
Tennessee Titans
Prediction
06:00 PM
02/11/25
02/11/25
Pittsburgh Steelers
Indianapolis Colts
Prediction
02:30 PM
09/11/25
09/11/25
Indianapolis Colts
Atlanta Falcons
Prediction
06:00 PM
23/11/25
23/11/25
Kansas City Chiefs
Indianapolis Colts
Prediction
06:00 PM
30/11/25
30/11/25
Indianapolis Colts
Houston Texans
Prediction
06:00 PM
07/12/25
07/12/25
Jacksonville Jaguars
Indianapolis Colts
Prediction
09:25 PM
14/12/25
14/12/25
Seattle Seahawks
Indianapolis Colts
Prediction
01:15 AM
23/12/25
23/12/25
Indianapolis Colts
San Francisco 49ers
Prediction
06:00 PM
28/12/25
28/12/25
Indianapolis Colts
Jacksonville Jaguars
Prediction
06:00 PM
04/01/26
04/01/26
Houston Texans
Indianapolis Colts
Prediction
San Francisco 49ers Next Fixtures
NFL
08:05 PM
28/09/25
28/09/25
San Francisco 49ers
Jacksonville Jaguars
Prediction
12:15 AM
03/10/25
03/10/25
Los Angeles Rams
San Francisco 49ers
Prediction
05:00 PM
12/10/25
12/10/25
Tampa Bay Buccaneers
San Francisco 49ers
Prediction
12:20 AM
20/10/25
20/10/25
San Francisco 49ers
Atlanta Falcons
Prediction
05:00 PM
26/10/25
26/10/25
Houston Texans
San Francisco 49ers
Prediction
06:00 PM
02/11/25
02/11/25
New York Giants
San Francisco 49ers
Prediction
09:25 PM
09/11/25
09/11/25
San Francisco 49ers
Los Angeles Rams
Prediction
09:05 PM
16/11/25
16/11/25
Arizona Cardinals
San Francisco 49ers
Prediction
01:15 AM
25/11/25
25/11/25
San Francisco 49ers
Carolina Panthers
Prediction
06:00 PM
30/11/25
30/11/25
Cleveland Browns
San Francisco 49ers
Prediction
09:25 PM
14/12/25
14/12/25
San Francisco 49ers
Tennessee Titans
Prediction
01:15 AM
23/12/25
23/12/25
Indianapolis Colts
San Francisco 49ers
Prediction
01:20 AM
29/12/25
29/12/25
San Francisco 49ers
Chicago Bears
Prediction
06:00 PM
04/01/26
04/01/26
San Francisco 49ers
Seattle Seahawks
Prediction
Indianapolis Colts Last Match Played stats
Tennessee Titans vs Indianapolis Colts
Final Score :20 - 41
| (H) | Offense | (A) |
|---|---|---|
| 2 | Touchdowns | 5 |
| 2/4 | Field goals | 2/3 |
| 282 | Total yards | 365 |
| 1 | Turnovers | 0 |
| 2/2 | Red zone efficiency | 2/4 |
| 31:19 | Time of Possession | 28:41 |
| 21 | First downs | 22 |
| 3 | First downs by penalty | 2 |
| 5/14 (35%) | Third down efficiency | 2/8 (25%) |
| 1 | Punts | 1 |
| 52 | Average yards per punt | 46 |
| 4.3 | Average yards per play | 6.9 |
| (H) | Passing | (A) |
| 11 | First downs by passing | 10 |
| 196 | Net yards passing | 228 |
| 219 | Gross yards passing | 228 |
| 1 | Passing touchdowns | 1 |
| 1 | Interceptions thrown | 0 |
| 4.7 | Average passing yards per attempt | 9.1 |
| 4 | Red zone passing attempts | 0 |
| (H) | Rushing | (A) |
| 23 | Rushing attempts | 28 |
| 86 | Rushing yards | 137 |
| 3.7 | Average rushing yards per attempt | 4.9 |
| 8 | First downs by rushing | 9 |
| 6 | Red zone rushing attempts | 6 |
| (H) | Other | (A) |
| 8 | Penalties | 4 |
| 68 | Yards penalized | 23 |
| 0 | Fumbles | 0 |
| 0 | Fumbles lost | 0 |
San Francisco 49ers Last Match Played stats
San Francisco 49ers vs Arizona Cardinals
Final Score :16 - 15
| (H) | Offense | (A) |
|---|---|---|
| 1 | Touchdowns | 1 |
| 3/3 | Field goals | 2/3 |
| 355 | Total yards | 260 |
| 1 | Turnovers | 0 |
| 1/4 | Red zone efficiency | 1/3 |
| 25:21 | Time of Possession | 34:39 |
| 19 | First downs | 16 |
| 1 | First downs by penalty | 1 |
| 2/10 (20%) | Third down efficiency | 5/15 (33%) |
| 3 | Punts | 5 |
| 42.7 | Average yards per punt | 51.6 |
| 5.7 | Average yards per play | 4.1 |
| (H) | Passing | (A) |
| 14 | First downs by passing | 8 |
| 282 | Net yards passing | 154 |
| 284 | Gross yards passing | 159 |
| 1 | Passing touchdowns | 1 |
| 1 | Interceptions thrown | 0 |
| 6.7 | Average passing yards per attempt | 4.3 |
| 4 | Red zone passing attempts | 3 |
| (H) | Rushing | (A) |
| 20 | Rushing attempts | 28 |
| 73 | Rushing yards | 106 |
| 3.7 | Average rushing yards per attempt | 3.8 |
| 4 | First downs by rushing | 7 |
| 6 | Red zone rushing attempts | 2 |
| (H) | Other | (A) |
| 5 | Penalties | 5 |
| 69 | Yards penalized | 30 |
| 0 | Fumbles | 1 |
| 0 | Fumbles lost | 0 |
NFL 25/26 Standings
| POS | TEAM | MP | W | L | PTS |
|---|---|---|---|---|---|
| 1 |  San Francisco 49ers | 3 | 3 | 0 | 1 |
| 2 |  Philadelphia Eagles | 3 | 3 | 0 | 1 |
| 3 |  Los Angeles Chargers | 3 | 3 | 0 | 1 |
| 4 |  Indianapolis Colts | 3 | 3 | 0 | 1 |
| 5 |  Buffalo Bills | 3 | 3 | 0 | 1 |
| 6 |  Tampa Bay Buccaneers | 3 | 3 | 0 | 1 |
| 7 |  Seattle Seahawks | 4 | 3 | 1 | 0.75 |
| 8 |  Green Bay Packers | 3 | 2 | 1 | 0.667 |
| 9 |  Minnesota Vikings | 3 | 2 | 1 | 0.667 |
| 10 |  Cincinnati Bengals | 3 | 2 | 1 | 0.667 |
| 11 |  Detroit Lions | 3 | 2 | 1 | 0.667 |
| 12 |  Washington Commanders | 3 | 2 | 1 | 0.667 |
| 13 |  Pittsburgh Steelers | 3 | 2 | 1 | 0.667 |
| 14 |  Jacksonville Jaguars | 3 | 2 | 1 | 0.667 |
| 15 |  Los Angeles Rams | 3 | 2 | 1 | 0.667 |
| 16 |  Arizona Cardinals | 4 | 2 | 2 | 0.5 |
| 17 |  Cleveland Browns | 3 | 1 | 2 | 0.333 |
| 18 |  Atlanta Falcons | 3 | 1 | 2 | 0.333 |
| 19 |  Baltimore Ravens | 3 | 1 | 2 | 0.333 |
| 20 |  Chicago Bears | 3 | 1 | 2 | 0.333 |
| 21 |  Carolina Panthers | 3 | 1 | 2 | 0.333 |
| 22 |  Las Vegas Raiders | 3 | 1 | 2 | 0.333 |
| 23 |  Dallas Cowboys | 3 | 1 | 2 | 0.333 |
| 24 |  Denver Broncos | 3 | 1 | 2 | 0.333 |
| 25 |  Kansas City Chiefs | 3 | 1 | 2 | 0.333 |
| 26 |  New England Patriots | 3 | 1 | 2 | 0.333 |
| 27 |  New York Jets | 3 | 0 | 3 | 0 |
| 28 |  Miami Dolphins | 3 | 0 | 3 | 0 |
| 29 |  New York Giants | 3 | 0 | 3 | 0 |
| 30 |  Tennessee Titans | 3 | 0 | 3 | 0 |
| 31 |  New Orleans Saints | 3 | 0 | 3 | 0 |
| 32 |  Houston Texans | 3 | 0 | 3 | 0 |