Chicago Cubs vs St. Louis Cardinals: Prediction, Head-to-Head, Odds & Stats (Fri, 26 Sep '25)

On Friday, September 26, 2025, the Chicago Cubs will square off against the St. Louis Cardinals in what promises to be an intriguing matchup in the MLB tournament. As fans and analysts alike prepare for this encounter, we delve into the statistics to draw insights and craft predictions on who might emerge victorious.

When examining the head-to-head history over the last 10 games between these two teams, it’s apparent that they are evenly matched, with each team securing five wins apiece. But what narrative will unfold this time? Could either team tip the balance in their favor with a decisive performance? Let’s consider their last meeting on August 10, 2025, when the Cardinals managed a narrow 3-2 victory at home.

Digging deeper into the stats of that particular game, both teams showed similar prowess. The Cubs and the Cardinals each had zero home runs, illustrating a balanced competition on the batting front. Fielding statistics mirrored this equality, with both teams recording zero putouts. Such parity raises the question: does either team hold an undisclosed advantage that could determine the upcoming contest?

Momentum is an elusive yet powerful force in sports, and both teams approach this game on the back of defeats by the Cincinnati Reds. The Cubs suffered a 4-7 loss, while the Cardinals conceded a 2-6 game. Could these recent setbacks fuel a desire to bounce back, or will they signal vulnerability?

Based on the analysis of these statistics and the historical balance in their head-to-head records, this encounter is poised to be fiercely competitive. However, given the detailed scrutiny of past performances and current forms, it seems the St. Louis Cardinals might just edge out the Chicago Cubs, capitalizing on their recent home win against them. But in the unpredictable world of baseball, only time will unveil the reality on the diamond.